Insufficient Non-REM Sleep Intensity in Narcolepsy-Cataplexy
نویسندگان
چکیده
منابع مشابه
Challenging sleep homeostasis in narcolepsy-cataplexy: implications for non-REM and REM sleep regulation.
STUDY OBJECTIVES We recently proposed insufficient non-rapid eye movement sleep (NREMS) intensity to contribute to disturbed nocturnal sleep in patients with narcolepsy-cataplexy (NC). To test this hypothesis, we investigated the effect of physiologically intensified NREMS in recovery sleep following sleep deprivation. DESIGN Nocturnal baseline and recovery sleep architecture, and the sleep e...
متن کاملControl of trigeminal motoneuron behavior and masseter muscle tone during REM sleep, REM sleep behavior disorder and cataplexy/narcolepsy
Sleep markedly affects fundamental mechanisms of motor control. Sleep not only suppresses postural muscle tone (Brooks and Peever, 2008b; Burgess et al., 2008), but it also attenuates, and in some cases even abolishes motor reflexes (e.g., H-reflex) (Wills and Chase, 1979). Mechanisms of motor control are also differentially affected by prevailing behavioral state. For example, muscle tone and ...
متن کاملAntidepressants substantially affect basic REM sleep characteristics in narcolepsy-cataplexy patients.
OBJECTIVES Antidepressants substantially affect REM sleep characteristics and trigger manifestations of REM sleep behavior disorder (RBD) in the general, non-narcoleptic, population. Antidepressants are also frequently administrated in an attempt to suppress cataplexy. We investigated the role of antidepressants in the development of RBD in narcolepsy with cataplexy (NC) patients. PATIENTS/ME...
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A patient is reported in whom signs and symptoms of REM sleep behavior disorder (RBD) and narcolepsy have been associated for almost two decades with a late development of parkinsonism and rheumatoid arthritis. A 78-year-old male patient in whom RBD was first diagnosed was followed-up by clinical examination, video-polysomnography, multiple sleep latency test, cerebral magnetic resonance imagin...
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Sodium oxybate (SO; Xyrem®) has been approved in most countries for treatment of narcolepsy and cataplexy. In this study, we present a single-center experience of a series of 18 patients with narcolepsy with cataplexy (18/18 DQB1*0602 positive, 17/17 with low/absent cerebrospinal fluid hypocretin) in whom SO was prescribed. After 26 ± 13 months, 13/18 patients were still on SO at a mean dosage ...
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ژورنال
عنوان ژورنال: Sleep
سال: 2007
ISSN: 0161-8105,1550-9109
DOI: 10.1093/sleep/30.8.980